Cefditoren
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| Systematic (IUPAC) name |
| (7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((Z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Clinical data |
| Trade names |
Spectracef |
| AHFS/Drugs.com |
monograph |
| MedlinePlus |
a605003 |
| Pregnancy cat. |
? |
| Legal status |
? |
| Identifiers |
| CAS number |
104145-95-1  N |
| ATC code |
J01DD16 |
| PubChem |
CID 9870843 |
| ChemSpider |
8046534  Y |
| UNII |
81QS09V3YW Y |
| KEGG |
D07639 N |
| ChEBI |
CHEBI:59343 Y |
| Chemical data |
| Formula |
C19H18N6O5S3 |
| Mol. mass |
506.58 g/mol |
| SMILES |
eMolecules & PubChem |
InChI
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InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1 Y
Key:KMIPKYQIOVAHOP-YLGJWRNMSA-N Y
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 N(what is this?) (verify)
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Cefditoren is a third-generation cephalosporin antibiotic for oral use. It is commonly marketed under the trade name Spectracef by Cornerstone BioPharma.
Cefditoren is also marketed under the name Meiact.1
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Contents
- 1 Clinical use
- 1.1 Indications
- 1.2 Formulations
- 2 References
- 3 External links
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Clinical use
Main article: Cephalosporin
Indications
Cefditoren is used to treat uncomplicated skin and skin structure infections, community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis (ABECB), pharyngitis, and tonsillitis.
Formulations
Cefditoren is available as 200 and 400 mg tablets. It can be formulated as the prodrug cefditoren pivoxil.
Chemical structure of cefditoren pivoxil
References
- ^ Meiact Full Description
External links
- Manufacturer's Product website
- Manufacturer's prescribing information for Spectracef
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Antibacterials: cell envelope antibiotics (J01C-J01D)
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| Intracellular |
inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin) • DADAL/AR inhibitors (Cycloserine) • bactoprenol inhibitors (Bacitracin)
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| Glycopeptide |
inhibit PG chain elongation: Vancomycin# (Oritavancin, Telavancin) • Teicoplanin (Dalbavancin) • Ramoplanin
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β-lactams/
(inhibit PBP
cross-links) |
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Penicillins
(penams)
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Extended sp.
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aminopenicillins: Amoxicillin# • Ampicillin# (Pivampicillin, Hetacillin, Bacampicillin, Metampicillin, Talampicillin) • Epicillin
carboxypenicillins: Carbenicillin (Carindacillin) • Ticarcillin • Temocillin
ureidopenicillins: Azlocillin • Piperacillin • Mezlocillin
other: Mecillinam (Pivmecillinam) • Sulbenicillin
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Narrow sp.
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β-lactamase sensitive
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Benzylpenicillin (G)#: Clometocillin • Benzathine benzylpenicillin# • Procaine benzylpenicillin# • Azidocillin • Penamecillin
Phenoxymethylpenicillin (V) #: Propicillin • Benzathine phenoxymethylpenicillin • Pheneticillin
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β-lactamase resistant
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Cloxacillin# (Dicloxacillin, Flucloxacillin) • Oxacillin • Meticillin • Nafcillin
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Penems
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Faropenem
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Carbapenems
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Biapenem • Ertapenem • antipseudomonal (Doripenem • Imipenem • Meropenem) • Panipenem
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Cephalosporins/Cephamycins
(cephems)
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1st (PEcK)
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Cefazolin# • Cefacetrile • Cefadroxil • Cefalexin • Cefaloglycin • Cefalonium • Cefaloridine • Cefalotin • Cefapirin • Cefatrizine • Cefazedone • Cefazaflur • Cefradine • Cefroxadine • Ceftezole
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2nd (HEN)
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Cefaclor • Cefamandole • Cefminox • Cefonicid • Ceforanide • Cefotiam • Cefprozil • Cefbuperazone • Cefuroxime • Cefuzonam • cephamycin (Cefoxitin, Cefotetan, Cefmetazole) • carbacephem (Loracarbef)
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3rd
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Cefixime# • Ceftriaxone# • antipseudomonal (Ceftazidime# • Cefoperazone) • Cefcapene • Cefdaloxime • Cefdinir • Cefditoren • Cefetamet • Cefmenoxime • Cefodizime • Cefotaxime • Cefpimizole • Cefpiramide • Cefpodoxime • Cefsulodin • Cefteram • Ceftibuten • Ceftiolene • Ceftizoxime • oxacephem (Flomoxef, Latamoxef ‡)
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4th (antips-)
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Cefepime • Cefozopran • Cefpirome • Cefquinome
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5th
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Ceftobiprole • Ceftaroline fosamil
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Veterinary
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Ceftiofur • Cefquinome • Cefovecin
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Monobactams
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Aztreonam • Tigemonam • Carumonam • Nocardicin A
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β-lactamase inh.
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penam (Sulbactam, Tazobactam) • clavam (Clavulanic acid)
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Combinations
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Amoxicillin/clavulanic acid# • Imipenem/cilastatin# • Ampicillin/flucloxacillin • Ampicillin/sulbactam (Sultamicillin) • Piperacillin/tazobactam
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| Other |
polymyxins/detergent (Colistin, Polymyxin B) • depolarizing (Daptomycin) • hydrolyze NAM-NAG (Lysozyme) • Gramicidin
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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gr+f/gr+a(t)/gr-p(c)/gr-o
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