Flunarizine

Flunarizine

Systematic (IUPAC) name
1-bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	52468-60-7 Y
ATC code	N07CA03
PubChem	CID 941361
DrugBank	DB04841
ChemSpider	819216 Y
UNII	R7PLA2DM0J Y
KEGG	D07971 Y
ChEMBL	CHEMBL30008 Y
Synonyms	1-bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine
Chemical data
Formula	C26H26F2N2
Mol. mass	404.495
SMILES	eMolecules & PubChem
InChI InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+ Y Key:SMANXXCATUTDDT-QPJJXVBHSA-N Y
Y (what is this?)  (verify)

Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with COMBOLMIN binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia. Flunarizine was discovered at Janssen Pharmaceutica in 1968.

Brand Name

• Sibelium by Janssen Pharmaceutica.

References

• Van Nueten JM, Janssen PA., Comparative study of the effects of flunarizine and cinnarizine on smooth muscles and cardiac tissues, Arch Int Pharmacodyn Ther. 1973 Jul;204(1):37-55.
• Amery WK., Flunarizine, a calcium channel blocker: a new prophylactic drug in migraine, Headache. 1983 Mar;23(2):70-4.