Magnesium Sulfate
| Magnesium sulfate |
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IUPAC name
Magnesium sulfate
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other names
Epsom salt
Bitter salts
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| Identifiers |
| CAS number |
7487-88-9  Y,
14168-73-1 (monohydrate)
24378-31-2 (tetrahydrate)
15553-21-6 (pentahydrate)
13778-97-7 (hexahydrate)
10034-99-8 (heptahydrate) |
| PubChem |
24083 |
| ChemSpider |
22515 |
| RTECS number |
OM4500000 |
| Properties |
| Molecular formula |
MgSO4 |
| Molar mass |
120.366 g/mol (anhydrous)
246.47 g/mol (heptahydrate) |
| Appearance |
white crystalline solid |
| Density |
2.66 g/cm3 (anhydrous)
2.445 g/cm3 (monohydrate)
1.68 g/cm3 (heptahydrate) |
| Melting point |
1124 °C (anhydrous, decomp)
200 °C (monohydrate, decomp)
150 °C (heptahydrate, decomp)
|
| Solubility in water |
anhydrous
26.9 g/100 mL (0 °C)
25.5 g/100 mL (20 °C)
heptahydrate
71 g/100 mL (20 °C) |
| Solubility |
0.0116 g/100 mL (18 °C, ether)
slightly soluble in alcohol, glycerol
insoluble in acetone |
| Refractive index (nD) |
1.523 (monohydrate)
1.433 (heptahydrate) |
| Structure |
| Crystal structure |
monoclinic (hydrate) |
| Hazards |
| MSDS |
External MSDS |
| EU Index |
Not listed |
| Related compounds |
| Other cations |
Beryllium sulfate
Calcium sulfate
Strontium sulfate
Barium sulfate |
 Y (what is this?) (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
| Infobox references |
Magnesium sulfate (or magnesium sulphate) is a chemical compound containing magnesium, sulfur and oxygen, with the formula MgSO4. In its hydrated form the pH is 6.0 (5.5 to 6.5). It is often encountered as the heptahydrate, MgSO4·7H2O, commonly called Epsom salt. Anhydrous magnesium sulfate is used as a drying agent. Since the anhydrous form is hygroscopic (readily absorbs water from the air) and is therefore difficult to weigh accurately, the hydrate is often preferred when preparing solutions, for example in medical preparations. Epsom salt has been traditionally used as a component of bath salts.
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Contents
- 1 Properties
- 2 Occurrence
- 3 Applications
- 4 References
- 5 External links
|
Properties
Magnesium sulfate is the primary substance that causes the absorption of sound in seawater.1 Absorption, in this case, means the conversion of acoustic energy to heat energy. The conversion is a strong function of frequency. Lower frequencies are less affected by the salt, so that the acoustic energy travels much farther in the ocean. Boric acid also contributes to absorption, and the most abundant salt in seawater, sodium chloride, has no known effect on sound absorption.
Occurrence
Magnesium sulfates are common minerals in geological environments. Their occurrence is mostly connected with supergene processes. Some of them are also important constituents of evaporitic potassium-magnesium (K-Mg) salts deposits. Almost all known mineralogical forms of MgSO4 occur as hydrates. Epsomite is the natural analogue of "Epsom salt," mentioned above. Another heptahydrate, the copper-containing mineral alpersite (Mg,Cu)SO4·7H2O2, was also recently recognized. Both are however not the highest known hydrates of MgSO4, due to the recent terrestrial find of meridianiite, MgSO4·11H2O, which is thought to also occur on Mars. Hexahydrite is the next lower (6) hydrate. Three next lower hydrates - pentahydrite (5), starkeyite (4) and especially sanderite (2) are more rarely found. Kieserite is a monohydrate and is common among evaporitic deposits. Anhydrous magnesium sulfate was reported from some burning coal dumps, but never treated as a mineral.
Applications
In agriculture and gardening, magnesium sulfate is used to correct magnesium deficiency in soil, since magnesium is an essential element in the chlorophyll molecule. It is most commonly applied to potted plants, or to magnesium-hungry crops, such as potatoes, roses, tomatoes, peppers and cannabis. The advantage of magnesium sulfate over other magnesium soil amendments (such as dolomitic lime) is its high solubility.
Anhydrous magnesium sulfate is commonly used as a desiccant in organic synthesis due to its affinity for water. During work-up, an organic phase is saturated with magnesium sulfate until it no longer forms clumps. The hydrated solid is then removed with filtration or decantation. Other inorganic sulfate salts such as sodium sulfate and calcium sulfate may also be used in the same way.
Magnesium sulfate is used in bath salts, particularly in flotation therapy where high concentrations raise the bath water's specific gravity, effectively making the body more buoyant. This property is also used to restore some Lava lamps damaged by being shaken by exchanging the water and adding drops of a concentrated solution until sustainable buoyancy is reached. Traditionally, it is also used to prepare foot baths, intended to soothe sore feet. The reason for the inclusion of the salt is partially cosmetic: the increase in ionic strength prevents some of the temporary skin wrinkling ("pruning" -- partial maceration) which is caused by prolonged immersion of extremities in pure water. However, magnesium sulfate can also be absorbed into the skin, reducing inflammation. It is also sometimes found in bottled mineral water, and accordingly is sometimes listed in the contents thereof. It may also be used as a coagulant for making tofu.3
Magnesium sulfate heptahydrate is also used to maintain the magnesium concentration in marine aquaria which contain large amounts of stony corals as it is slowly depleted in their calcification process. In a magnesium-deficient marine aquarium calcium and alkalinity concentrations are very difficult to control because not enough magnesium is present to stabilize these ions in the saltwater and prevent their spontaneous precipitation into calcium carbonate.4 It is also recommended for dropsy treatment for fish.5
An old remedy for diarrhea in adult chickens is 1/2 tsp per bird per day added to their feed.6
Magnesium sulfate is used as the electrolyte to prepare copper sulfate. A magnesium sulfate solution is electrolyzed with a copper anode to form copper sulfate, copper hydroxide, and hydrogen.
Medical use
Further information: Hypomagnesemia
Oral magnesium sulfate is commonly used as a saline laxative. Epsom salt is also available in a gel form for topical application in treating aches and pains.
Indications for its use are
- Replacement therapy for hypomagnesemia.7
- Magnesium sulfate is the first-line antiarrhythmic agent for torsades de pointes in cardiac arrest under the 2005 ECC guidelines and for managing quinidine-induced arrhythmias.8
- As a bronchodilator after beta-agonist and anticholinergic agents have been tried, e.g. in severe exacerbations of asthma.9 Recent studies have revealed that magnesium sulfate can be nebulized to reduce the symptoms of acute asthma.9 It is commonly administered via the intravenous route for the management of severe asthma attacks.
- A 2004 research study showed that both magnesium and sulfate are absorbed through the skin when bathing in 1% w/v solution.10
- Magnesium sulfate can be used to treat eclampsia in pregnant women.11
- Magnesium sulfate can also delay labor in the case of premature labor, to delay preterm birth.1213
- Intravenous magnesium sulfate may be able to prevent cerebral palsy in preterm babies.14
- Solutions of sulfate salts such as Epsom salt may be given as first aid for barium chloride poisoning.15
- Magnesium sulfate paste has been used as an agent for dehydrating (drawing) boils, carbuncles, and abscesses.16
- Magnesium sulfate solution has also been shown to be an effective aid in the fight against blemishes and acne when applied directly to problematic areas, usually in poultice form.17 If combined with water and made into a cream, it can be applied to the face to remove blackheads.
- Magnesium sulfate, when used through soaking, can soothe muscle pains and help improve rough patches in the skin.18
- Soaking in a warm bath containing Epsom salt (magnesium sulfate) can be beneficial to soothe and relieve herpes outbreak symptoms, such as itching and lesions relating to genital herpes and shingles.1920
References
- ^ "Underlying physics and mechanisms for the absorption of sound in seawater". Resource.npl.co.uk. http://resource.npl.co.uk/acoustics/techguides/seaabsorption/physics.html. Retrieved 2009-07-06.
- ^ Peterson, Ronald C.; Hammarstrom, Jane M.; Seal, II, Robert R (Feb 2006). "Alpersite (Mg,Cu)SO4·7H2O, a new mineral of the melanterite group, and cuprian pentahydrite: Their occurrence within mine waste". American Mineralogist 91 (2-3): 261–269. doi:10.2138/am.2006.1911.
- ^ "Process for producing packed tofu". http://www.freepatentsonline.com/6042851.html.
- ^ "Do-It-Yourself Magnesium Supplements for the Reef Aquarium". Reefkeeping. 2006. http://reefkeeping.com/issues/2006-07/rhf/index.php. Retrieved 2008-03-14.
- ^ "Dropsy". www.healthybetta.com. 2004. http://www.healthybetta.com/articles/Illness%20Diagonsis/dropsy.html. Retrieved 2007-05-20.
- ^ "Old Time Remedies for Common Poultry Diseases". Mother Earth News. March 1974. http://www.motherearthnews.com/Sustainable-Farming/1974-03-01/Old-Time-Remedies.aspx. Retrieved 2008-03-05.
- ^ "Pharmaceutical Information - MAGNESIUM SULFATE". RxMed. http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20M)/MAGNESIUM%20SULFATE.html. Retrieved 2009-07-06.
- ^ "When clicking citation, it is listed under ''Other medicinal and home uses''". Disabled-world.com. 2007-01-04. http://www.disabled-world.com/artman/publish/epsom-salts.shtml. Retrieved 2009-07-06.
- ^ a b Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, Rowe BH. Aerosolized magnesium sulfate for acute asthma: a systematic review. Chest 2005;128:337-44. PMID 16002955.
- ^ Rosemary Waring Absorption of magnesium sulphate through the skin (republished by the Epsom Salt Council), 2004
- ^ BBC News story 'Simple jab averts pregnancy danger' [1] 30 May 2002
- ^ "Magnesium sulfate for preterm labor". Webmd.com. 2007-01-19. http://www.webmd.com/baby/magnesium-sulfate-for-preterm-labor. Retrieved 2009-07-06.
- ^ Lewis DF (September 2005). "Magnesium sulfate: the first-line tocolytic". Obstet. Gynecol. Clin. North Am. 32 (3): 485–500. doi:10.1016/j.ogc.2005.03.002. PMID 16125045. http://journals.elsevierhealth.com/retrieve/pii/S0889-8545(05)00010-0.
- ^ "Epsom salt can prevent cerebral palsy: U.S. study". Reuters.com. 2008-01-31. http://www.reuters.com/article/healthNews/idUSHUN17633820080131?sp=true. Retrieved 2009-07-06.
- ^ "When clicking citation, it is ''Number 4'' on the list". Jtbaker.com. http://www.jtbaker.com/msds/englishhtml/b0372.htm. Retrieved 2009-07-06.
- ^ "How to Get Rid of Boils". Getridofthings.com. http://www.getridofthings.com/get-rid-of-boils.htm. Retrieved 2009-07-06.
- ^ "Acne guide". Frihost.com. http://www.frihost.com/forums/vt-51486.html. Retrieved 2009-07-06.
- ^ "When clicking citation, it is ''Number 10''". Articlesbase.com. 2009-01-31. http://www.articlesbase.com/diseases-and-conditions-articles/10-tips-to-reduce-muscle-pain-naturally-without-side-effects-749262.html. Retrieved 2009-07-06.
- ^ "Herpes Home Remedies" Herpes and Cold Sores Support Network
- ^ "McKinley Health Center - Genital Herpes - University of Illinois" McKinley Health Center, University of Illinois
External links
- A06AD04
- A12CC02
- B05XA05
- D11AX05
- V04CC02
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Magnesium compounds |
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MgB2 · MgBr2 · MgCO3 · MgC6H6O7 · MgC14H10O4 · MgCl2 · Mg(ClO4)2 · MgF2 · MgH2 · MgI2 · Mg(NO3)2 · MgO · MgO2 · Mg(OH)2 · MgS · MgSO3 · MgSO4 · MgU2O7 · Mg2Si · Mg2Si3O8 · Mg3N2 · Mg3(PO4)2
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Laxatives and cathartics (A06) |
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| Softeners, emollients |
Paraffin · Docusate sodium
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| Contact laxatives |
Oxyphenisatine · Bisacodyl · Dantron · Phenolphthalein · Castor oil · Senna glycosides · Cascara · Sodium picosulfate · Bisoxatin
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| Bulk producers |
Ispaghula · Ethulose · Sterculia · Linseed · Methylcellulose · Triticum · Polycarbophil calcium
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| Osmotically acting laxatives |
Magnesium carbonate · Magnesium oxide · Magnesium peroxide · Magnesium sulfate · Lactulose · Lactitol · Sodium sulfate · Pentaerythritol · Macrogol · Mannitol · Sodium phosphate · Sorbitol · Magnesium citrate · Sodium tartrate
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| Enemas |
Sodium laurilsulfate · Sodium phosphate · Bisacodyl · Dantron · Glycerol · Oil · Sorbitol
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| Peripheral opioid antagonists |
Alvimopan · Methylnaltrexone · Oxycodone/naloxone
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| Prostaglandins |
Lubiprostone
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Mineral supplements (A12) |
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| Calcium |
Calcium phosphate · Calcium glubionate · Calcium gluconate · Calcium carbonate · Calcium lactate · Calcium lactate gluconate · Calcium chloride · Calcium glycerylphosphate · Calcium citrate · Calcium citrate lysine complex · Calcium glucoheptonate · Calcium pangamate
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| Potassium |
Potassium chloride · Potassium citrate · Potassium hydrogentartrate · Potassium hydrogencarbonate · Potassium gluconate
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| Sodium |
Sodium chloride · Sodium sulfate
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| Zinc |
Zinc sulfate · Zinc gluconate
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| Magnesium |
Magnesium chloride · Magnesium sulfate · Magnesium gluconate · Magnesium citrate · Magnesium aspartate · Magnesium lactate · Magnesium levulinate · Magnesium pidolate · Magnesium orotate · Magnesium oxide
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| Fluoride |
Sodium fluoride · Sodium monofluorophosphate
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| Selenium |
Sodium selenate · Sodium selenite
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Antianemic preparations (B03), blood substitutes and perfusion solutions (B05), and other hematological agents (B06) |
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| Antianemic preparations |
Ferrous glycine sulfate · Ferrous fumarate · Ferrous gluconate · Ferrous carbonate · Ferrous chloride · Ferrous succinate · Ferrous sulfate · Ferrous tartrate · Ferrous aspartate · Ferrous ascorbate · Ferrous iodine
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| Blood substitutes and perfusion solutions |
Serum albumin · Dextran · Gelatin agents · Hydroxyethylstarch · Hemoglobin crosfumaril · Hemoglobin raffimer · Sorbitol
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| Other hematological agents |
Fibrinolysin · Desoxyribonuclease · Hyaluronidase · Chymotrypsin · Trypsin · Desoxyribonuclease · Bromelain
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Antiarrhythmic agents (C01B) |
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| Channel blockers |
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class I
(Na+ channel blockers)
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class Ia (Phase 0→ and Phase 3→)
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Procainamide # • Quinidine # • Ajmaline • Disopyramide • Prajmaline • Sparteine
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class Ib (Phase 3←)
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IV (Lidocaine #) • enteral (Mexiletine, Tocainide, Aprindine)
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class Ic (Phase 0→)
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Encainide • Flecainide • Lorcainide • Moricizine • Propafenone
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class III
(Phase 3→, K+ channel blockers)
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Amiodarone • Bretylium • Bunaftine • Dofetilide • Ibutilide • Nifekalant • Sotalol • Tedisamil • E-4031
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class IV
(Phase 4→, Ca2+ channel blockers)
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Verapamil # • Diltiazem
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Receptor agonists
and antagonists |
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class II
(Phase 4→, β blockers)
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Propranolol • Nadolol • Pindolol • cardioselective (Atenolol, Metoprolol, Acebutolol, Esmolol)
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A1 agonist
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Adenosine
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M2
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muscarinic antagonist: Atropine • Quinidine • Disopyramide
muscarinic agonist: Digoxin
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α receptors
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Quinidine • Verapamil • Amiodarone • Bretylium
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| Ion transporters |
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# = WHO-EM
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Other dermatological preparations (D11) |
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| Medicated shampoos |
Cetrimide - Cadmium compounds - Selenium compounds - Povidone-iodine - Sulfur compounds - Xenysalate
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| Other dermatologicals |
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Seborrhoeic dermatitis/dandruff
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Lithium succinate · Pyrithione zinc
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Skin whitening/depigmenting
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Hydroquinone · Mequinol · Monobenzone
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Anti-inflammatory/Immunomodulators
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Oxaceprol · Gamolenic acid · Pimecrolimus · Tacrolimus · Alitretinoin
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Baldness treatments
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5-alpha-reductase inhibitor (Finasteride) · potassium channel opener (Minoxidil)
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Hair growth inhibitors
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Eflornithine
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Other
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Calcium gluconate · Magnesium sulfate · Tiratricol
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Other gynecologicals (G02C) |
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| Labor |
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Tocolytics/
labor repressants
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β2-agonists: Ritodrine · Buphenine · Fenoterol · Terbutaline
oxytocin antagonist: Atosiban
NSAID: Indometacin
calcium channel blocker: Nifedipine
Magnesium sulfate
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Uterotonics/
labor inducers
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cervical ripening: prostaglandins (Misoprostol, Dinoprostone)
contraction induction: Oxytocin
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| Prolactin inhibitors |
Bromocriptine · Lisuride · Cabergoline · Quinagolide · Metergoline · Terguride
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Anti-inflammatory products
for vaginal administration |
Ibuprofen · Naproxen · Benzydamine · Flunoxaprofen
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Diagnostic agents (V04) |
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| Digestive system |
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Diabetes
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Tolbutamide · Glucose
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Fat absorption
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Vitamin A concentrates
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Bile duct patency
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Sorbitol · Magnesium sulfate · Sincalide · Ceruletide
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Liver functional capacity
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Galactose · Sulfobromophthalein
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Gastric secretion
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Cation exchange resins · Betazole · Histamine phosphate · Pentagastrin · Methylthioninium chloride · Caffeine and sodium benzoate
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Exocrine pancreatic function
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Secretin · Pancreozymin (cholecystokinin) · Bentiromide
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| Endocrine system |
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Pituitary function
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cortisol: Metyrapone · Corticorelin
GH: Sermorelin · Somatorelin
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Thyroid function
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Thyrotropin · Protirelin
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Fertility disturbances
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Gonadorelin
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| Tuberculosis |
Tuberculin
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| Renal function |
Inulin and other polyfructosans · Indigo carmine · Phenolsulfonphthalein · Alsactide · Aminohippuric acid
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