Nisoldipine
 |
| Systematic (IUPAC) name |
| isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Clinical data |
| Trade names |
Sular |
| AHFS/Drugs.com |
monograph |
| MedlinePlus |
a696009 |
| Pregnancy cat. |
C (US) |
| Legal status |
℞-only (US) |
| Routes |
Oral |
| Pharmacokinetic data |
| Protein binding |
99% |
| Half-life |
7-12 hours |
| Identifiers |
| CAS number |
63675-72-9  Y |
| ATC code |
C08CA07 |
| PubChem |
CID 4499 |
| IUPHAR ligand |
2524 |
| DrugBank |
DB00401 |
| ChemSpider |
4343  N |
| UNII |
4I8HAB65SZ N |
| KEGG |
D00618 Y |
| ChEMBL |
CHEMBL1726 N |
| Chemical data |
| Formula |
C20H24N2O6 |
| Mol. mass |
388.414 g/mol |
 N (what is this?) (verify)
|
Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. It sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels. 1
External links
- DDB 30009
- Mielcarek J, Grobelny P, Szamburska O (2005). "The effect of beta-carotene on the photostability of nisoldipine.". Methods Find Exp Clin Pharmacol 27 (3): 167–71. doi:10.1358/mf.2005.27.3.890873. PMID 15834448.
- Missan S, Zhabyeyev P, Dyachok O, Jones SE, McDonald TF (November 2003). "Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine". Br. J. Pharmacol. 140 (5): 863–70. doi:10.1038/sj.bjp.0705518. PMC 1574108. PMID 14530219. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1574108.
- Hamilton S, Houle L, Thadani U (1999). "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.". Heart Dis 1 (5): 279–88. PMID 11720635.
References
- ^ http://www.sciencedirect.com/science/article/pii/S0002914999804469; Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?
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Channel blockers
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| Calcium (Ca2+) |
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| Potassium (K+) |
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