Ornidazole - Wikipedia, the free encyclopedia

Ornidazole

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Not to be confused with ronidazole.
Ornidazole
Systematic (IUPAC) name
1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Routes Oral
Pharmacokinetic data
Metabolism Metabolised via the liver, excreted in the Urine and Feces
Excretion 85% of single oral dose is elimiated with 5 days - Urine (63%) and Feces (22%)
Identifiers
CAS number 16773-42-5 YesY
ATC code G01AF06 J01XD03 P01AB03 QP51AA03
PubChem CID 28061
ChemSpider 26102 YesY
UNII 62XCK0G93T YesY
KEGG D05274 YesY
Chemical data
Formula C7H10ClN3O3 
Mol. mass 219.625
SMILES eMolecules & PubChem
 YesY (what is this?)  (verify)

Ornidazole is a drug that cures some protozoan infections. It is used by the poultry industry.

It has been investigated for use in Crohn's disease after bowel resection.1

References

  1. ^ Rutgeerts P, Van Assche G, Vermeire S, et al. (April 2005). "Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial". Gastroenterology 128 (4): 856–61. doi:10.1053/j.gastro.2005.01.010. PMID 15825069. http://linkinghub.elsevier.com/retrieve/pii/S0016508505000302. 
  • v
  • t
  • e
Antibacterials: nucleic acid inhibitors (J01E, J01M)
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)
DHFR inhibitor
  • 2,4-Diaminopyrimidine
    • Trimethoprim#
    • Brodimoprim
    • Tetroxoprim
    • Iclaprim†
Sulfonamides
(DHPS inhibitor)
Short-
acting
  • Sulfaisodimidine
  • Sulfamethizole
  • Sulfadimidine
  • Sulfapyridine
  • Sulfafurazole
  • Sulfanilamide
    • Prontosil
  • Sulfathiazole
  • Sulfathiourea
Intermediate-
acting
  • Sulfamethoxazole
  • Sulfadiazine#
  • Sulfamoxole
Long-
acting
  • Sulfadimethoxine
  • Sulfadoxine
  • Sulfalene
  • Sulfametomidine
  • Sulfametoxydiazine
  • Sulfamethoxypyridazine
  • Sulfaperin
  • Sulfamerazine
  • Sulfaphenazole
  • Sulfamazone
Other/ungrouped
  • sulfanilamide
    • Sulfacetamide
    • Sulfametrole
Combinations
  • Trimethoprim/sulfamethoxazole#
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)
1st g.
  • Cinoxacin‡
  • Flumequine
  • Nalidixic acid
  • Oxolinic acid
  • Pipemidic acid
  • Piromidic acid
  • Rosoxacin
Fluoro-
quinolones
2nd g.
  • Ciprofloxacin#
  • Enoxacin‡
  • Fleroxacin‡
  • Lomefloxacin
  • Nadifloxacin
  • Ofloxacin
  • Norfloxacin
  • Pefloxacin
  • Rufloxacin
3rd g.
  • Balofloxacin
  • Grepafloxacin‡
  • Levofloxacin
  • Pazufloxacin
  • Sparfloxacin‡
  • Temafloxacin‡
  • Tosufloxacin
4th g.
  • Besifloxacin
  • Clinafloxacin†
  • Garenoxacin
  • Gemifloxacin
  • Moxifloxacin
  • Gatifloxacin‡
  • Sitafloxacin
  • Trovafloxacin‡/Alatrofloxacin‡
  • Prulifloxacin
Vet.
  • Danofloxacin
  • Difloxacin
  • Enrofloxacin
  • Ibafloxacin
  • Marbofloxacin
  • Orbifloxacin
  • Pradofloxacin
  • Sarafloxacin
Related (DG)
  • Aminocoumarins: Novobiocin
Anaerobic DNA
inhibitors
Nitro- imidazole derivatives
  • Metronidazole#
  • Tinidazole
  • Ornidazole
Nitrofuran derivatives
  • Nitrofurantoin#
  • Furazolidone‡
  • Nifurtoinol
RNA synthesis
Rifamycins/
RNA polymerase
  • Rifampicin#
  • Rifabutin
  • Rifapentine
  • Rifaximin
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)
  • v
  • t
  • e
Gynecological anti-infectives and antiseptics (G01)
Antibiotics
  • Candicidin
  • Chloramphenicol
  • Hachimycin
  • Oxytetracycline
  • Carfecillin
  • Mepartricin
  • Clindamycin
  • Pentamycin
Arsenic compounds
  • Acetarsol
Quinoline derivatives
  • Diiodohydroxyquinoline
  • Clioquinol
  • Chlorquinaldol
  • Dequalinium
  • Broxyquinoline
  • Oxyquinoline
Organic acids
  • Lactic acid
  • Acetic acid
  • Ascorbic acid
Sulfonamides
  • Sulfatolamide
Antifungals
Imidazoles
  • Metronidazole
  • Clotrimazole
  • Miconazole
  • Econazole
  • Ornidazole
  • Isoconazole
  • Tioconazole
  • Ketoconazole
  • Fenticonazole
  • Azanidazole
  • Propenidazole
  • Butoconazole
  • Omoconazole
  • Oxiconazole
  • Flutrimazole
Triazoles
  • Terconazole
Polyenes
  • Nystatin
  • Natamycin
  • Amphotericin B
Other
  • Ciclopirox
  • Methylrosaniline
Other
  • Clodantoin
  • Inosine
  • Policresulen
  • Nifuratel
  • Furazolidone
  • Povidone-iodine
  • Protiofate
  • Lactobacillus fermentum
  • Copper usnate

M: ♀ FRS

anat/phys/devp

noco/cong/npls, sysi/epon

proc/asst, drug (G1/G2B/G3CD)
  • v
  • t
  • e
Antiparasitics – antiprotozoal agents – agents against amoebozoa/amebicide (P01)
Entamoeba
Tissue amebicides
Nitroimidazole derivatives
  • Metronidazole#
  • Tinidazole
  • Ornidazole
  • Nimorazole
  • Secnidazole
  • Azanidazole
  • Propenidazole
Other
  • isoquinoline (Emetine/Dehydroemetine)
Luminal amebicides
Hydroxyquinoline derivatives
  • Cl (Chlorquinaldol)
  • Br (Tilbroquinol
  • Broxyquinoline)
  • I (Diiodohydroxyquinoline)
  • I,Cl (Clioquinol)
  • related: Chiniofon
Dichloroacetamide derivatives
  • Diloxanide#
  • Clefamide
  • Etofamide
  • Teclozan
Aminoglycoside
  • Paromomycin
Other/ungrouped
  • arsenic (Arsthinol
  • Difetarsone
  • Glycobiarsol)
  • phenanthroline (Phanquinone)
  • aminoacridine (Mepacrine)
  • quinazoline (Trimetrexate)
  • thiazole (Tenonitrozole)
  • sesquiterpene (Fumagillin)
Acanthamoeba
  • Propamidine
  • Chlorhexidine
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

M: PRO

ambz, excv, chrm (strc)

ambz, excv, chrm

ambz, excv, chrm


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