Oxaprozin

Oxaprozin

Systematic (IUPAC) name
3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
Clinical data
Trade names	Daypro
AHFS/Drugs.com	monograph
MedlinePlus	a693002
Pregnancy cat.	C
Legal status	?
Routes	Oral
Pharmacokinetic data
Bioavailability	95%
Protein binding	99%
Metabolism	Liver—65% oxidation and 35% glucuronic acid conjugation. 5% are active phenolic metabolites.
Half-life	54.9 hours
Identifiers
CAS number	21256-18-8
ATC code	M01AE12
PubChem	CID 4614
DrugBank	DB00991
ChemSpider	4453 Y
UNII	MHJ80W9LRB Y
KEGG	D00463 Y
ChEMBL	CHEMBL1071 Y
Chemical data
Formula	C18H15NO3
Mol. mass	293.317 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21) Y Key:OFPXSFXSNFPTHF-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Oxaprozin, also known as Oxaprozinum, (sold under the names: Daypro, Dayrun, Duraprox) is a non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. It is available in 600 mg tablets. Normal adult dosage is 1200 mg daily, not to exceed 1800 mg per day. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.