Voglibose - Wikipedia, the free encyclopedia

Voglibose

From Wikipedia, the free encyclopedia
Jump to: navigation, search
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (September 2009)
Voglibose
Systematic (IUPAC) name
(1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 83480-29-9 YesY
ATC code A10BF03
PubChem CID 444020
DrugBank DB04878
ChemSpider 392046 YesY
UNII S77P977AG8 YesY
KEGG D01665 YesY
ChEMBL CHEMBL476960 YesY
Chemical data
Formula C10H21NO7 
Mol. mass 267.28 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Voglibose (INN and USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Voglibose delays the absorption of glucose thereby reduces the risk of macrovascular complications. Voglibose is a research product of Takeda Pharma , A Japan based company.

Postprandial hyperglycemia (PPHG) is primarily due to first phase insulin secretion. Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal.

There are three drugs which belong to this class, acarbose, miglitol and voglibose, of which voglibose is the newest. Voglibose scores over both acarbose and miglitol in terms of side effect profile. But acarbose has an edge over voglibose in terms of efficacy (FPG, PPHG, HBA1c).

There are several trials supporting the use of voglibose in the management of PPHG. Also, it has been established that it is PPHG, not FPG, which is the marker of cardiovascular disorders associated with diabetes. So, controlling PPHG is imperative and voglibose is indicated for the management of PPHG.

External links

  • diabetesincontrol.com
  • diabetesjournals.org
  • Ranbaxy announcement
  • v
  • d
  • e
Oral anti-diabetic drugs and Insulin analogs (A10)
Insulin
Sensitizers
Biguanides
Metformin# • Buformin‡ • Phenformin‡
TZDs (PPAR)
Pioglitazone • Rivoglitazone† • Rosiglitazone • Troglitazone‡
Dual PPAR agonist
Aleglitazar† • Muraglitazar§ • Tesaglitazar§
Secretagogues
K+ ATP
Sulfonylureas

1st generation: Acetohexamide • Carbutamide • Chlorpropamide • Metahexamide • Tolbutamide • Tolazamide

2nd generation: Glibenclamide (Glyburide)# • Glibornuride • Glipizide • Gliquidone • Glisoxepide • Glyclopyramide  • Glimepiride  • Gliclazide
Meglitinides/"glinides"
Nateglinide • Repaglinide • Mitiglinide
GLP-1 analogs
Exenatide • Liraglutide • Taspoglutide† • Albiglutide† • Lixisenatide
DPP-4 inhibitors
Alogliptin† • Linagliptin • Saxagliptin • Sitagliptin • Vildagliptin
Analogs/other insulins
fast-acting (Insulin lispro • Insulin aspart • Insulin glulisine) • short-acting (Regular insulin) • long-acting (Insulin glargine • Insulin detemir • NPH insulin) • ultra-long-acting (Insulin degludec†) • inhalable Exubera‡
Other
Alpha-glucosidase inhibitors
Acarbose • Miglitol • Voglibose
Amylin analog
Pramlintide
SGLT2 inhibitors
Canagliflozin† • Dapagliflozin† • Remogliflozin§ • Sergliflozin§
Other
Benfluorex‡ • Tolrestat‡
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)


Stub icon This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.